To evaluate CNS depression, anxiolytic and anti-epileptic activity of methanolic extract of Trichosanthus dioca (METD) in experimental animals. CNS depression activity of METD (300mg/kg, p.o.) was measured using open field behavior model using diazepam (2 mg/kg, p.o) as a reference standard. Anxiolytic activity was performed using elevated plus maze model using diazepam (2mg/kg, p.o.) as a reference standard. The anti-epileptic activity of METD (300mg/kg, p.o.) was performed using MES model using Phenytoin (25mg/kg, p.o.) as a reference standard. In open field model MELTD showed significant reduction in no. of square crossed (21 ± 10.06) and no. of rearing (6.25 ± 1.93) as compared to control (68 ± 15.74, 15.75 ± 2.49) (p< 0.05). In elevated plus maze model METD showed significant increased in time spent in open arm (109.75 ± 6.38) as compared to control (69 ± 8.58). In MES model METD showed significant decreased in extension, stupor and total recovery as compared to control. Methanolic extract of Trichosanthus dioca fruit showed significant CNS depression, anxiolytic and anti-epileptic activity in experimental animals.
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